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Scientific studies on Tibetan Medicine

 

Studies on clinical effects of Tibetan whole formulas


Indication Title Reference1 Link
Atherosclerosis (intermittent claudication) Treating intermittent claudication with Tibetan medicine Padma 28: does it work? Melzer 2006 abstract
  Efficacy and safety of Padma 28 in peripheral arterial occlusive disease [Article in German, English abstract available] Melzer 2006 abstractDabstractE
  Complementary therapies for peripheral arterial disease: systematic review Pittler 2005 abstract
  Padma-28, a herbal preparation, increases walking distance in patients with intermittent claudication [Article in Danish] Drabaek 1994 abstract
  Effects of the Tibetan herbal preparation PADMA 28 on blood lipids and lipid oxidisability in subjects with mild hypercholesterolaemia. Brunner-La Rocca 2005 abstract
  A botanical compound, Padma 28, increases walking distance in stable intermittent claudication. Drabaek 1993 abstract
  Treatment of chronic ischemia of the lower extremities with complex herbal preparation. [Article in Polish, English abstract available] Smulski 1991 abstract
  Effects of the Tibetan herbal preparation Padma 28 in intermittent claudication. [Article in German, English abstract available] Schräder 1985 abstract
  A lamaistic formula for the treatment of peripheral arterial occlusive diseases. [Article in German, no abstract available] Hürlimann  
Irritable bowel disease Herbal medicines for treatment of irritable bowel syndrome. Liu 2006 abstract
  A novel treatment for constipation-predominant irritable bowel syndrome using Padma Lax, a Tibetan herbal formula. Sallon 2002 abstract
Constipation Treatment of a tetraplegic patient with chronic constipation with the Tibetan remedy Padma Lax - a case report [Article in German] Feldhaus 2006 abstractDabstractE
Arthritis Efficacy of the Tibetan treatment for arthritis. Ryan 1997 abstract
  Immune function of rheumatoid arthritis treated by medicated-bath therapy in Tibetan medicine. [Article in Chinese, English abstract available] Zhao 1993 abstract
Ophtalmology Treatment of corneal disease with traditional Tibetan medicine: A report of four cases Yangkyi 2011 pdf
Midwifery Randomized double masked trial of Zhi Byed 11, a Tibetan traditional medicine, versus misoprostol to prevent postpartum hemorrhage in Lhasa, Tibet Miller 2009 pdf
Dental pulpitis Padma 28 in the treatment of chronic dental pulpitis: an observational case study in 49 patients [Article in German, English abstract available] Füllemann 2006 abstractDabstractE
Inhibition of side effects of fluoxetine Clinical study on effect of fluoxetine combined with Chinese medicine or tibetan drugs in treating senile depression in plateau district. [Article in Chinese] Zhang 2006 English abstract
Multiple sclerosis Current Complementary and Alternative Therapies for Multiple Sclerosis. Bowling 2003 abstract
Diabetes mellitus Efficacy of Tibetan medicine as an adjunct in the treatment of type 2 diabetes. Namdul 2001 full text
Recurrent respiratory tract infections Immunostimulation in recurrent respiratory tract infections therapy in children. Prusek 1987 abstract

 

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1References clinical data:

Bowling AC, Stewart TM. Current Complementary and Alternative Therapies for Multiple Sclerosis. Curr Treat Options Neurol 2003;5:55-68.
Brunner-La Rocca HP, Schindler R, Schlumpf M, Saller R, Suter M. Effects of the Tibetan herbal preparation PADMA 28 on blood lipids and lipid oxidisability in subjects with mild hypercholesterolaemia. Vasa 2005;34:11-7.
Drabaek H, Mehlsen J, Petersen JR, Himmelstrup H, Hansen KF. [Padma-28, a herbal preparation, increases walking distance in patients with intermittent claudication]. Ugeskr Laeger 1994;156:6207-9. [Article in Danish]
Drabaek H, Mehlsen J, Himmelstrup H, Winther K. A botanical compound, Padma 28, increases walking distance in stable intermittent claudication. Angiology 1993;44:863-7.
Feldhaus S. [Treatment of a tetraplegic patient with chronic constipation with the Tibetan remedy Padma Lax--a case report].Forsch Komplementmed 2006;13 Suppl 1:31-2. [Article in German]
Füllemann F. [Padma 28 in the treatment of chronic dental pulpitis: an observational case study in 49 patients]. Forsch Komplementmed 2006;13 Suppl 1:28-30. [Article in German]
Hürlimann F. [A lamaistic formula for the treatment of peripheral arterial occlusive diseases (author's transl)]. Schweiz Rundsch Med Prax 1978;67:1407-9. [Article in German, no abstract available]
Liu JP, Yang M, Liu YX, Wei ML, Grimsgaard S. Herbal medicines for treatment of irritable bowel syndrome. Cochrane Database Syst Rev 2006;1:CD004116.
Melzer J, Brignoli R, Diehm C, Reichling J, Do DD, Saller R. Treating intermittent claudication with Tibetan medicine Padma 28: does it work? Atherosclerosis 2006;189:39-46.
Melzer J, Brignoli R, Saller R. [Efficacy and safety of Padma 28 in peripheral arterial occlusive disease]. Forsch Komplementmed 2006;13 Suppl 1:23-7. [Article in German]
Miller S, Tudor C, Thorsten V, Nyima, Kalyang, Sonam, Lhakpen, Droyoung, Quzong K, Dekyi T, Hartwell T, Wright LL, Varner MW. Randomized double masked trial of Zhi Byed 11, a Tibetan traditional medicine, versus misoprostol to prevent postpartum hemorrhage in Lhasa, Tibet. J Midwifery Womens Health 2009;54:133-141.
Namdul T, Sood A, Ramakrishnan L, Pandey RM, Moorthy D. Efficacy of Tibetan medicine as an adjunct in the treatment of type 2 diabetes. Diabetes Care 2001;24:175-6.
Pittler MH, Ernst E. Complementary therapies for peripheral arterial disease: systematic review. Atherosclerosis 2005;181:1-7.
Prusek W, Jankowski A, Radomska G, Wieczorek E, Podwysocka M. Immunostimulation in recurrent respiratory tract infections therapy in children. Arch Immunol Ther Exp (Warsz) 1987;35:289-302.
Ryan M. Efficacy of the Tibetan treatment for arthritis. Soc Sci Med 1997;44:535-9.
Sallon S, Ben-Arye E, Davidson R, Shapiro H, Ginsberg G, Ligumsky M. A novel treatment for constipation-predominant irritable bowel syndrome using Padma Lax, a Tibetan herbal formula. Digestion 2002;65:161-71.
Schräder R, Nachbur B, Mahler F. [Effects of the Tibetan herbal preparation Padma 28 in intermittent claudication]. Schweiz Med Wochenschr 1985;115:752-6. [Article in German, English abstract available]
Smulski HS. [Treatment of chronic ischemia of the lower extremities with complex herbal preparation]. Ann Acad Med Stetin 1991;37:191-202. [Article in Polish, English abstract available]
Yangkyi T, Waller SG. Treatment of corneal disease with traditional Tibetan medicine: A report of four cases. Nepal J Ophthalmol 2011;3:83-5.
Zhang HW, Wang CY, Xu HN, et al. [Clinical study on effect of fluoxetine combined with Chinese medicine or tibetan drugs in treating senile depression in plateau district]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006;26:202-4. [Article in Chinese].
Zhao SL, Geng PL, Sang J. [Immune function of rheumatoid arthritis treated by medicated-bath therapy in Tibetan medicine]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993;13:467-70, 452-3. [Article in Chinese, English abstract available]


 

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Non clinical studies with Tibetan whole formulas


Effect Title Reference 2 Link
antiatherogenic Anti-inflammatory mechanisms of the Tibetan herbal preparation Padma 28 in the vessel wall. Exner 2006 abstract
  Anti-inflammatory potential of Padma 28--review of experimental data on the antiatherogenic activity and discussion of the multi-component principle. [Article in German, English abstract available] Ueberall 2006 abstract
  Padma 28 modifies immunological functions in experimental atherosclerosis in rabbits. Giełdanowski 1992 abstract
anti-inflammatory PADMA-28, a Tibetan herbal preparation is an inhibitor of inflammatory cytokine production. Barak 2004 pdf
  PADMA 28 modulates interferon-gamma-induced tryptophan degradation and neopterin production in human PBMC in vitro. Neurauter 2004 abstract
immune modulating Mechanisms of immunotropic effect of the drug composition Taban-Arshan (Tibet medicine) on lymphocytes of patients with early rheumatoid arthritis and atopic bronchial asthma. [Article in Russian, English abstract available]
Semenova 2005 abstract
  Taban-Arshan: immunocorrector in atopic bronchial asthma. Semenova 2004 abstract
  Inhibition of inducible nitric oxide synthesis by the herbal preparation Padma 28 in macrophage cell line. Moeslinger 2000 abstract
  The effect of Padma-28, a traditional Tibetan herbal preparation, on human neutrophil function. Matzner 1995 abstract
antioxidative Novel chemiluminescence-inducing cocktails, part II: measurement of the anti-oxidant capacity of vitamins, thiols, body fluids, alcoholic beverages and edible oils. Ginsburg 2004 abstract
  Anti- and pro-oxidative properties of PADMA 28, a Tibetan herbal formulation. Suter 2000 abstract
hepatoprotective Amelioration of hepatic fibrosis via Padma Hepaten is associated with altered natural killer T lymphocytes. Ginsburg 2009 pdf
  Hepatoprotective effect of Tibetan remedy "Dig-Da-Shi-Tan". [Article in Russian, English abstract available] Nikolaev 2005 abstract
  Effect of hepatophyt on the choleretic function of the liver damaged by tetracycline. [Article in Russian, English abstract available] Nikolaev 2003 abstract
  Inhibition of ethanol-induced changes in rats by Padma 28. Wójcicki 1989 abstract
antiproliferative, proapoptotic Antiproliferative properties of Padma Lax and its components ginger and elecampane. Hofbauer 2006 abstract
  Apoptosis induced by the Tibetan herbal remedy PADMA 28 in the T cell-derived lymphocytic leukaemia cell line CEM-C7H2. Jenny 2005 pdf
  PADMA-28, a traditional Tibetan herbal preparation, blocks cellular responses to bFGF and IGF-I. Navab 2004 abstract
neuroprotective The herbal preparation Padma 28 protects against neurotoxicity in PC12 cells. Ginsburg 2011 abstract
  The therapeutic effect of an herbal formula Badmaev 28 (padma 28) on experimental allergic encephalomyelitis (EAE) in SJL/J mice.
Badmaev 1999 abstract
skin protection, wound healing A multi-component herbal preparation (PADMA 28) improves structure/function of corticosteroid-treated skin, leading to improved wound healing of subsequently induced abrasion wounds in rats. Aslam 2010 abstract
  PADMA 28: a multi-component herbal preparation with retinoid-like dermal activity but without epidermal effects.
Aslam 2005 pdf
gastrointestinal motility Effects of the Tibetan herbal formula Padma Lax on visceral nociception and contractility of longitudinal smooth muscle in a rat model. Gschossmann 2010 abstract
locally modulation of microcirculation In vivo effects of Pain Relieving Plaster on closed soft tissue injury in rabbit ears. Wang 2008 pdf
antimicrobial Comparative investigation of the antimicrobial activity of PADMA 28 and selected European herbal drugs. Weseler 2002 abstract
cell protective, antiproteolytic PADMA-28, a traditional tibetan herbal preparation inhibits the respiratory burst in human neutrophils, the killing of epithelial cells by mixtures of oxidants and pro-inflammatory agonists and peroxidation of lipids.
Ginsburg 1999 abstract
cardioprotective Effect of Tibetan compound prescription on cardiac haemodynamics in experimental myocardial ischemia in dogs. [Article in Chinese, English abstract available] Zhang 1995 abstract

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2References non clinical studies:

Aslam MN, Warner RL, Bhagavathula N, Ginsburg I, Varani J. A multi-component herbal preparation (PADMA 28) improves structure/function of corticosteroid-treated skin, leading to improved wound healing of subsequently induced abrasion wounds in rats. Arch Dermatol Res 2010;302:669-77.
Aslam MN, Fligiel H, Lateef H, Fisher GJ, Ginsburg I, Varani J. PADMA 28: a multi-component herbal preparation with retinoid-like dermal activity but without epidermal effects. J Invest Dermatol 2005;124:524-9.
Badmaev V, Kozlowski PB, Schuller-Levis GB, Wisniewski HM. The therapeutic effect of an herbal formula Badmaev 28 (padma 28) on experimental allergic encephalomyelitis (EAE) in SJL/J mice. Phytother Res 1999;13:218-21.
Barak V, Kalickman I, Halperin T, Birkenfeld S, Ginsburg I. PADMA-28, a Tibetan herbal preparation is an inhibitor of inflammatory cytokine production. Eur Cytokine Netw 2004;15:203-9.
Exner M, Raith M, Holzer G, Gmeiner B, Wagner O, Kapiotis S. Anti-inflammatory mechanisms of the Tibetan herbal preparation Padma 28 in the vessel wall. Forsch Komplementmed. 2006;13 Suppl 1:13-7.
Giełdanowski J, Dutkiewicz T, Samochowiec L, Wójcicki J. Padma 28 modifies immunological functions in experimental atherosclerosis in rabbits. Arch Immunol Ther Exp (Warsz) 1992;40:291-5.
Ginsburg I, Rozenstein-Tsalkovich L, Koren E, Rosenmann H. The herbal preparation Padma 28 protects against neurotoxicity in PC12 cells. Phytother Res 2011;25:740-3.
Ginsburg I, Koren E, Horani A, et al. Amelioration of hepatic fibrosis via Padma Hepaten is associated with altered natural killer T lymphocytes. Clin Exp Immunol 2009;157:155-64.
Ginsburg I, Sadovnic M, Oron M, Kohen R. Novel chemiluminescence-inducing cocktails, part II: measurement of the anti-oxidant capacity of vitamins, thiols, body fluids, alcoholic beverages and edible oils. Inflammopharmacology 2004;12:305-20.
Ginsburg I, Sadovnik M, Sallon S, et al. PADMA-28, a traditional tibetan herbal preparation inhibits the respiratory burst in human neutrophils, the killing of epithelial cells by mixtures of oxidants and pro-inflammatory agonists and peroxidation of lipids. Inflammopharmacology 1999;7:47-62.
Gschossmann JM, Krayer M, Flogerzi B, Balsiger BM. Effects of the Tibetan herbal formula Padma Lax on visceral nociception and contractility of longitudinal smooth muscle in a rat model. Neurogastroenterol Motil 2010;22:1036-41.
Hofbauer S, Kainz V, Golser L, et al. Antiproliferative properties of Padma Lax and its components ginger and elecampane. Forsch Komplementmed. 2006;13 Suppl 1:18-22.
Jenny M, Schwaiger W, Bernhard D, et al. Apoptosis induced by the Tibetan herbal remedy PADMA 28 in the T cell-derived lymphocytic leukaemia cell line CEM-C7H2. J Carcinog. 2005;4:15.
Matzner Y, Sallon S. The effect of Padma-28, a traditional Tibetan herbal preparation, on human neutrophil function. J Clin Lab Immunol 1995;46:13-23.
Moeslinger T, Friedl R, Volf I, Brunner M, Koller E, Spieckermann PG. Inhibition of inducible nitric oxide synthesis by the herbal preparation Padma 28 in macrophage cell line. Can J Physiol Pharmacol 2000;78:861-6.
Navab R, Aingorn H, Fallavollita L, et al. PADMA-28, a traditional Tibetan herbal preparation, blocks cellular responses to bFGF and IGF-I. Inflammopharmacology 2004;12:373-89.
Neurauter G, Wirleitner B, Schroecksnadel K, Schennach H, Ueberall F, Fuchs D. PADMA 28 modulates interferon-gamma-induced tryptophan degradation and neopterin production in human PBMC in vitro. Int Immunopharmacol 2004;4:833-9.
Nikolaev SM, Sambueva ZG, Aseeva TA, Chekhirova GV. [Hepatoprotective effect of Tibetan remedy "Dig-Da-Shi-Tan"]. Antibiot Khimioter 2005;50:23-6. [Article in Russian, English abstract available]
Nikolaev SM, Sambueva ZG, Chekhirova GV, Tsyrenzhalov AV. [Effect of hepatophyt on the choleretic function of the liver damaged by tetracycline]. Antibiot Khimioter 2003;48:24-6. [Article in Russian, English abstract available]
Semenova LIu, Salmasi ZhM, Kazimirskiĭ AN, Poriadin GV. [Mechanisms of immunotropic effect of the drug composition Taban-Arshan (Tibet medicine) on lymphocytes of patients with early rheumatoid arthritis and atopic bronchial asthma]. Patol Fiziol Eksp Ter 2005;(1):23-5. [Article in Russian]
Semenova LY, Salmasi ZhM, Kazimirskii AN, Poryadin GV. Taban-Arshan: immunocorrector in atopic bronchial asthma. Bull Exp Biol Med 2004;138:65-6.
Suter M, Richter C. Anti- and pro-oxidative properties of PADMA 28, a Tibetan herbal formulation. Redox Rep 2000;5:17-22.
Ueberall F, Fuchs D, Vennos C. [Anti-inflammatory potential of Padma 28--review of experimental data on the antiatherogenic activity and discussion of
the multi-component principle]. Forsch Komplementmed. 2006;13 Suppl 1:7-12. [Article in German, English abstract available]
Wang YZ, Guo CY, Zhong HG, Zhang WN, Wang DL, Wang X, Dong FH. In vivo effects of Pain Relieving Plaster on closed soft tissue injury in rabbit ears. BMC Complement Altern Med. 2008;8:51.
Weseler A, Saller R, Reichling J. Comparative investigation of the antimicrobial activity of PADMA 28 and selected European herbal drugs. Forsch Komplementarmed Klass Naturheilkd 2002;9:346-51.
Wójcicki J, Samochowiec L, Kadłubowska D. Inhibition of ethanol-induced changes in rats by Padma 28. Acta Physiol Pol 1989;40:387-92.
Zhang YJ, Hou Y, Cao YB. [Effect of Tibetan compound prescription on cardiac haemodynamics in experimental myocardial ischemia in dogs]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1995;15:231-3. [Article in Chinese, English abstract available]


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PubMed Live Search*

Pubmed live search For the most up-to-date list of PubMed-indexed studies** on complex remedies from Tibetan Medicine click the PubMed-icon*

* Search terms: (tibet OR tibetan OR lamaistic) AND (herbal formula OR herbal preparation OR botanical compound OR plant mixture OR medicinal product OR multi-component OR multi-compound OR multicompound OR multi-herbal OR remedy)

** PubMed is a free database maintained by the United States National Library of Medicine, which indexes and shows abstracts of scientific articles on medicine, life sciences and biomedical topics. Over 8000 journaly on medical topics are indexed, for a complent list of PubMed-indexed journals see the following link.

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